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DeCS
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Descriptor English:
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Agouti Signaling Protein
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Descriptor Spanish:
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proteína de señalización Agouti
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Descriptor Portuguese:
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Proteína Agouti Sinalizadora
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Synonyms English:
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ASIP Protein
Agouti Protein
Agouti Switch Protein
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Tree Number:
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D12.644.276.049
D12.776.467.049
D23.529.049
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Definition English:
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A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans. |
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History Note English:
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2008 (1993)
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Allowable Qualifiers English:
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Record Number:
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52758
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Unique Identifier:
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D054366
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Occurrence in VHL:
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Similar:
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DeCS
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